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Kisspeptin
Kisspeptin is a hypothalamic peptide that activates the gonadotropin-releasing hormone (GnRH) system upstream of the entire reproductive axis. Studied for hypothalamic amenorrhea, hypogonadism, and libido.
Kisspeptin at a glance
Kisspeptin is a hypothalamic peptide that activates the gonadotropin-releasing hormone (GnRH) system upstream of the entire reproductive axis. Studied for hypothalamic amenorrhea, hypogonadism, and libido. Mechanism: Hypothalamic neuropeptide. Typical route: Subcutaneous, intranasal. FDA status: Not FDA-approved as a finished drug product. Used in clinical research and dispensed by specialty compounding pharmacies for off-label hypogonadism, hypothalamic amenorrhea, and libido protocols.
Drug classHypothalamic neuropeptide
Half-life~20-30 minutes
RouteSubcutaneous, intranasal
Common dosing50-200 mcg, 2-3x/week
FDA statusNot approved
Available throughCompounding pharmacies
Mechanism of action
Kisspeptin activates the KISS1R receptor on GnRH neurons in the hypothalamus, stimulating pulsatile GnRH release. GnRH then drives pituitary LH/FSH release, which in turn stimulates testicular testosterone or ovarian estradiol production. Kisspeptin therefore acts upstream of testosterone or HCG protocols.
Dosing reference
Subcutaneous: 50-200 mcg, two to three times weekly. Some protocols dose intranasally at higher amounts. Optimal dosing for sexual-health applications is not standardized.
Dosing information is provided for educational reference and is not medical advice. Patients should not initiate or modify any peptide regimen without consulting a licensed clinician. See our medical disclaimer.
FDA status & regulatory framework
Not FDA-approved as a finished drug product. Used in clinical research and dispensed by specialty compounding pharmacies for off-label hypogonadism, hypothalamic amenorrhea, and libido protocols.
U.S. telehealth providers that work with Kisspeptin
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76/100v3.0 six-pillar rubric
Starting at $149/mo. Maximus is covered in our editorial directory and works with peptides in the sexual-health category.
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Starting at $149/mo. Hone Health is covered in our editorial directory and works with peptides in the sexual-health category.
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Frequently asked questions about Kisspeptin
How does kisspeptin differ from testosterone replacement?
Testosterone replacement suppresses the body's own hormone production. Kisspeptin activates the body's natural GnRH-LH-testosterone axis, preserving (or restoring) endogenous production rather than replacing it.
Can kisspeptin be used during testosterone replacement?
Combining kisspeptin with exogenous testosterone may not produce additive effects; testosterone replacement suppresses the upstream HPG axis. Kisspeptin is most useful where preserving endogenous production matters (fertility, post-cycle therapy, hypothalamic amenorrhea).