Ozempic vs Wegovy — what's the difference?

Both are semaglutide manufactured by Novo Nordisk. Ozempic is FDA-approved for type 2 diabetes (max 2.0 mg). Wegovy is FDA-approved for chronic weight management (max 2.4 mg) and cardiovascular risk reduction. Same active ingredient, different FDA labels and prices.

Semaglutide vs tirzepatide — which produces more weight loss?

In SURPASS-2 (NEJM 2021, PMID 34170647), tirzepatide produced approximately 47% greater weight loss than semaglutide 1 mg. Tirzepatide is a dual GLP-1/GIP agonist; semaglutide is GLP-1-only. Semaglutide has uniquely demonstrated cardiovascular (SELECT) and kidney (FLOW) outcomes.

Compounded vs brand semaglutide — what should I know?

Same active ingredient. Brand (Ozempic, Wegovy, Rybelsus) is FDA-approved and manufactured by Novo Nordisk. Compounded is not FDA-approved and is dispensed by 503A or 503B pharmacies. Quality with reputable compounded providers is verified through USP , USP , and HPLC potency CoAs. Use only semaglutide base — avoid salt forms (semaglutide sodium/acetate) which have been targeted in FDA warning letters.

Compare Semaglutide Forms & Provider Programs

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$147 (6-mo, save $108) · $149 (3-mo, save $48) · $165 (monthly).

Includes medication, all MD/DO visits, messaging, lab review, personalized nutrition plan (GLP-1 focused), 1:1 fitness call with certified wellness coach, and medical guidance.

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Trade-offs to know

Compounded only — no brand-name Wegovy® / Ozempic® / Rybelsus®. Cash-pay with HSA/FSA only — no in-network insurance billing. Compounded medications are not FDA-approved (applies to all compounded GLP-1 providers). Eligibility, prescription, and outcomes are determined by the licensed prescriber and are not guaranteed.

Semaglutide forms head-to-head

Form	Manufacturer	FDA Indication	Cash price
Ozempic	Novo Nordisk	Type 2 diabetes	~$935-$1,000/mo
Wegovy	Novo Nordisk	Chronic weight management; CV risk reduction	~$1,349/mo
Rybelsus	Novo Nordisk	Type 2 diabetes (oral)	~$935/mo
Compounded semaglutide	503A or 503B pharmacy	Not FDA-approved	$145-$297/mo

Pivotal trial results

STEP-1 (NEJM 2021, PMID 33567185) — semaglutide 2.4 mg: 14.9% weight loss / 68 weeks vs 2.4% placebo
SUSTAIN-6 (NEJM 2016, PMID 27633186) — semaglutide CV safety in T2D + high CV risk
SELECT (NEJM 2023, PMID 37952131) — 20% MACE reduction in non-diabetic adults with overweight/obesity + CVD
FLOW (NEJM 2024, PMID 38785189) — 24% reduction in major kidney/CV events in T2D + CKD
SURPASS-2 (NEJM 2021, PMID 34170647) — tirzepatide ~47% greater weight loss vs semaglutide 1 mg

Compare Semaglutide Forms & Programs

Semaglutide forms head-to-head

Pivotal trial results

Detailed head-to-head pages