#1 of 3
71/100v3.0 six-pillar rubric
Starting at $125/mo. PeterMD is one of the providers covered in our editorial directory that dispenses or coordinates Dihexa.
Read review →Cognitive · HGF Activator
Dihexa
Dihexa is a small-molecule angiotensin IV analog studied as a hepatocyte growth factor (HGF) activator with strong neurogenic and pro-cognitive effects in animal models.
Dihexa at a glance
Dihexa is a small-molecule angiotensin IV analog studied as a hepatocyte growth factor (HGF) activator with strong neurogenic and pro-cognitive effects in animal models. Mechanism: HGF activator (Ang IV analog). Typical route: Oral, sublingual, intranasal. FDA status: Not FDA-approved. Available through specialty compounding pharmacies and research-chemical suppliers. Human safety and efficacy data is limited; most evidence is from animal models.
Drug classHGF activator (Ang IV analog)
Half-life~10 hours
RouteOral, sublingual, intranasal
Common dosing8-45 mg/day
FDA statusNot approved
Available throughCompounding pharmacies
Mechanism of action
Dihexa potentiates hepatocyte growth factor (HGF) binding to its c-Met receptor in the brain, stimulating synaptogenesis and dendritic spine formation. Preclinical models show enhanced memory and reversal of cognitive decline in Alzheimer's mouse models.
Dosing reference
Oral: 8-45 mg per day. Sublingual or intranasal formulations are also used. Dosing in human use is not standardized; protocols vary widely.
Dosing information is provided for educational reference and is not medical advice. Patients should not initiate or modify any peptide regimen without consulting a licensed clinician. See our medical disclaimer.
FDA status & regulatory framework
Not FDA-approved. Available through specialty compounding pharmacies and research-chemical suppliers. Human safety and efficacy data is limited; most evidence is from animal models.
U.S. telehealth providers that work with Dihexa
#2 of 3
85/100v3.0 six-pillar rubric
Starting at $180/mo. Marek Health is one of the providers covered in our editorial directory that dispenses or coordinates Dihexa.
Read review →#3 of 3
88/100v3.0 six-pillar rubric
Starting at $160/mo. Defy Medical is one of the providers covered in our editorial directory that dispenses or coordinates Dihexa.
Read review →Related cognitive enhancement peptides
Frequently asked questions about Dihexa
How strong is the evidence for Dihexa?
Animal-model evidence for cognitive enhancement and reversal of Alzheimer's-type deficits is robust. Human evidence is extremely limited; risk-benefit cannot be properly assessed without clinical trials.
Is Dihexa safe?
Long-term safety in humans is unknown. The compound's strong effects on growth-factor signaling raise theoretical concerns about cancer risk in long-term use; no clinical evidence either supports or refutes this concern.