#1 of 4
88/100v3.0 six-pillar rubric
Starting at $160/mo. Defy Medical is one of the providers covered in our editorial directory that dispenses or coordinates DSIP (Delta Sleep-Inducing Peptide).
Read review →Recovery · Sleep
DSIP (Delta Sleep-Inducing Peptide)
DSIP is a 9-amino-acid peptide first isolated from rabbit cerebral venous blood. Studied for sleep regulation, stress modulation, and circadian rhythm support.
DSIP (Delta Sleep-Inducing Peptide) at a glance
DSIP is a 9-amino-acid peptide first isolated from rabbit cerebral venous blood. Studied for sleep regulation, stress modulation, and circadian rhythm support. Mechanism: Sleep-modulating nonapeptide. Typical route: Subcutaneous or intranasal. FDA status: Not FDA-approved. Available through compounding pharmacies and research-chemical suppliers; quality control varies substantially.
Drug classSleep-modulating nonapeptide
Half-life~7 minutes (parenteral)
RouteSubcutaneous or intranasal
Common dosing100-500 mcg before bed
FDA statusNot approved
Available throughCompounding pharmacies
Mechanism of action
DSIP appears to modulate the hypothalamic-pituitary-adrenal (HPA) axis, reduce stress-induced cortisol elevation, and shift sleep architecture toward more delta (deep) sleep phases. Mechanism is incompletely understood; the peptide's named function (sleep induction) is supported more in animal models than in robust human trials.
Dosing reference
Subcutaneous or intranasal: 100-500 mcg taken 30-60 minutes before bedtime. Many protocols cycle 5-7 days on, then 2-3 days off, given the unclear long-term safety profile.
Dosing information is provided for educational reference and is not medical advice. Patients should not initiate or modify any peptide regimen without consulting a licensed clinician. See our medical disclaimer.
FDA status & regulatory framework
Not FDA-approved. Available through compounding pharmacies and research-chemical suppliers; quality control varies substantially.
U.S. telehealth providers that work with DSIP (Delta Sleep-Inducing Peptide)
#2 of 4
85/100v3.0 six-pillar rubric
Starting at $180/mo. Marek Health is one of the providers covered in our editorial directory that dispenses or coordinates DSIP (Delta Sleep-Inducing Peptide).
Read review →#3 of 4
70/100v3.0 six-pillar rubric
Starting at $110/mo. Heally is one of the providers covered in our editorial directory that dispenses or coordinates DSIP (Delta Sleep-Inducing Peptide).
Read review →#4 of 4
71/100v3.0 six-pillar rubric
Starting at $125/mo. PeterMD is one of the providers covered in our editorial directory that dispenses or coordinates DSIP (Delta Sleep-Inducing Peptide).
Read review →Related recovery peptides
Frequently asked questions about DSIP (Delta Sleep-Inducing Peptide)
Does DSIP actually improve sleep?
Evidence is mixed. Animal studies and small open-label human trials show modulation of sleep architecture, but well-controlled trials are limited. Some users report subjective sleep improvement; others see no effect.
Is DSIP addictive?
DSIP does not act on GABA-A receptors and is not associated with the dependence patterns seen with benzodiazepines or Z-drugs. Long-term safety data is limited.