Guide · Updated 2026-05-08

Semaglutide and Cardiovascular Health

Semaglutide is the first GLP-1 with an FDA-approved CV indication for non-diabetic patients. SELECT trial: 20% MACE reduction in non-diabetic adults with overweight/obesity + CVD.

EducationalUpdated 2026-05-08
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Editorial team
Dr. Sam Saberian · Lead Medical Researcher
Medical review by Alen A. Schwartz, MD · Edited by Julliana Edwards · Last updated 2026-05-11

Overview

Semaglutide is the first GLP-1 with an FDA-approved CV indication for non-diabetic patients. SELECT trial: 20% MACE reduction in non-diabetic adults with overweight/obesity + CVD.

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